Recent Research
Sugary beverages and genetic risk in relation to brain structure and incident dementia: a prospective cohort study.
A study published by The American Journal of Clinical Nutrition finds that moderate consumption of up to one cup per day of natural juices, such as 100% orange juice, lowers the risk of dementia compared to those who do not consume 100% juices. Inversely, consuming up to two cups per day of artificially sweetened beverages and more than two cups per day of sugar-sweetened beverages increases the risk of dementia.
Health effects of 100% fruit and vegetable juices: evidence from human subject intervention studies
A review showed that orange juice had no adverse effect on body weight and other anthropometric markers, supported by recent meta-analyses. Hesperidin, a plant compound in 100% orange juice, could lower systolic blood pressure and improve endothelial function while not negatively impacting lipid profiles. Its effect on cognitive function and microbiota modulation suggests interesting prospects for future research.
A narrative review on the role of hesperidin on metabolic parameters, liver enzymes, and inflammatory markers in nonalcoholic fatty liver disease
This review highlights how hesperidin, a flavonoid found in citrus fruits and 100% orange juice, may have on people with nonalcoholic fatty liver disease (NAFLD). Recent research has shown hesperidin may decrease the risk factors associated with NAFLD, including oxidative stress, inflammation, dyslipidemia, hyperglycemia and obesity. Future human clinical trials may be able to confirm the powerful abilities of hesperidin that is found in every glass of 100% orange juice.
100% Orange Juice Consumption is Associated with Socioeconomic Status, Improved Nutrient Adequacy, and Higher Bioactive Compounds Intake: Results from Brazilian National Dietary Survey 2017–2018
100% orange juice consumption was associated with higher intakes of energy, vitamin C, folate, calcium, magnesium, potassium, polyphenols, and carotenoids. There is no significant difference in fiber intake between consumers and non-consumers. 100% OJ consumers had a higher percentage of the population meeting the Estimated Average Requirement for vitamin A, vitamin C, vitamin D, folate, calcium and magnesium.
Dietary Polyphenols: What is the Estimated Intake in Population Studies With Adults and Elderly People?
This review examined Phenol-Explorer which contained data on 502 polyphenols in 452 foods and beverages. The most ingested subclasses of polyphenols in different countries were phenolic acids and flavonoids, and non-alcoholic beverages (coffee, tea, and orange juice) were the foods that most contributed to the intake of polyphenols. France had an average intake of 1,193±510 mg/day, with the main sources consisting of non-alcoholic beverages (coffee, tea, and orange juice) and fruit (apple, strawberry, and plum). Among the 50 foods with the highest total polyphenol (TP) content per serving, orange or orange juice, wine, tea, and apple were the main contributors included in this review.
Comparison of vitamin C and flavanones between freshly squeezed orange juices and commercial 100% orange juices from four European countries
Orange juices preserve their bioactive compounds during storage, with very little influence from the brand, country, industrial process or storage conditions. In this comparison between freshly squeezed and commercial orange juice the main bioactive compounds in commercial 100% juices appear at nutritionally significant levels to the freshly squeezed ones.
Effects of Hesperidin Supplementation on Cardiometabolic Markers: A Systematic Review and Meta-analysis of Randomized Controlled Trials
This systematic review and meta-analysis of 13 randomized controlled trials reviewed 735 participants of which 381 were in the hesperidin group and 378 were in the control group. The daily dose of hesperidin ranged between 500 and 1000mg and investigated the effect of this supplementation on several cardiometabolic markers. The results showed that hesperidin supplementation has lowering effects on fasting blood sugar, triglycerides, total cholesterol, and low-density lipoprotein cholesterol serum levels as well as lowering systolic blood pressure. Hesperidin is a naturally occurring flavonoid found almost exclusively in citrus and citrus juices.
Associations of sugary beverage consumption with chronic obstructive pulmonary disease (COPD), asthma, and asthma-COPD overlap syndrome: A prospective cohort study
This prospective cohort study included 210,339 participants from the UK Biobank, and 183,439 participants were included after further excluding individuals with either chronic obstructive pulmonary disease (COPD) or asthma at baseline. After a median of 11.6 years, 3,491 participants developed COPD, 4,645 with asthma, and 523 with asthma–chronic obstructive pulmonary disease overlap (ACOS). One cup of artificially sweetened beverages (ASB) a day was associated with a greater risk of ACOS and a higher intake of sugar-sweetened beverages (SSB) was associated with both COPD and asthma while moderate intake of 100% juice was inversely associated with COPD. The study was not able to categorize all juices but did highlight and conclude that moderate intake of both 100% orange and grapefruit juice might reduce COPD incidence.
Disproportionately higher cardiovascular disease risk and incidence with high fructose corn syrup sweetened beverage intake among black young adults–the CARDIA study
In a longitudinal study data from the Coronary Artery Risk Development in Young Adults was analyzed to assess the consumption of high fructose corn syrup (HFCS) sweetened beverages during young adulthood with the hypothesis that HFCS sweetened beverage intake increases the risk of cardiovascular disease (CVD) more among Black than White adults, and that regular intake of orange juice may be protective against CVD. Data was assessed between the ages of 18-39 years old with the average age of 24.5 years and enrollment began in 1985-86. Over 35 years there were 186 new CVD cases among black participants out of 2186 and 119 new CVD cases among white participants out of 2277. Results of this study were comparable to other research that shows 5 or more times a week of HFCS sweetened beverages are more likely to have coronary heart disease than less frequent users of HFCS and orange juice consumption appeared to have protective factors.
Influence of consuming coffee and other beverages in adolescence on risk of type 2 diabetes in adulthood
A cohort study with 41,317 women from the Nurses Health Study who completed a food frequency questionnaire regarding their diet in high school found that higher intake of coffee and 100% orange juice in adolescence was associated with a lower risk of Type 2 Diabetes (T2DM). However, higher intake of regular soda and iced tea was associated with a higher risk of T2DM. The data was used to examine adolescent beverage consumption and the risk of Type 2 Diabetes in adulthood.
The questionnaire examined beverage intake of coffee, tea, regular or diet soda, fruit juice, and milk. Beverage intake during adolescence was correlated to adulthood. Both 100% orange juice and caffeinated coffee in adolescence was significantly associated with a 17% and 14%, respectively, lower T2DM risk in adulthood among women who consumed >1 serving/day compared with individuals who did not drink coffee or orange juice. Higher intake of 100% orange resulted in lower risk for T2DM. Beverages such as apple and other 100% juices, diet soda, and milk did not have an association with T2DM risk later in adulthood. In contrast, regular soda and iced tea were associated with a higher risk for T2DM.
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- Carnauba et al. Jana. 2024, doi: 10.1080/27697061.2024.2318598.
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- Carnauba et al. Jana. 2024. doi : 10.1080/09637486.2024.2303034.
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- Alperet et al. J.Epidemiol. 2024. doi : 10.1007/s10654-024-01165-x.